2024 / 10th INTERNATIONAL PEER-REVIEWED PUBLICATIONS – EX VIVO CLINICAL APPROACH – CLINIC’N’CELL

Biomedicines 2024, 12, 2132

https://doi.org/10.3390/biomedicines12092132

Human Serum, Following Absorption of Fish Cartilage Hydrolysate, Promotes Dermal Fibroblast Healing through Anti-Inflammatory and Immunomodulatory Proteins

Julie Le Faouder, Aurélie Guého, Régis Lavigne, Fabien Wauquier, Line Boutin-Wittrant,
Elodie Bouvret, Emmanuelle Com, Yohann Wittrant* and Charles Pineau* (*co last-authors)

2024 / 9th INTERNATIONAL PEER-REVIEWED PUBLICATIONS – EX VIVO CLINICAL APPROACH – CLINIC’N’CELL

https://pubmed.ncbi.nlm.nih.gov/38543230/

Pharmaceutics. 2024 Feb 28;16(3):336. doi: 10.3390/pharmaceutics16030336.

Reduced Production of Pro-Inflammatory and Pro-Catabolic Factors by Human Serum Metabolites Derived from a Patented Saffron Extract Intake

Line Pourtau ¹, Fabien Wauquier ², Line Boutin-Wittrant ², David Gaudout ¹, Benjamin Moras ¹, Adeline Vignault ¹, Carole Vaysse ³, Tristan Richard ^4 5, Arnaud Courtois ^4 5, Stéphanie Krisa ^4 5, Véronique Roux ⁶, Nicolas Macian ⁶, Gisèle Pickering ⁶, Yohann Wittrant ^2 7 8

2024 / 8th INTERNATIONAL PEER-REVIEWED PUBLICATIONS TO ATTEST THE ROBUSTNESS AND EFFICIENCY OF EX VIVO CLINICAL APPROACH – CLINIC’N’CELL

https://pubmed.ncbi.nlm.nih.gov/37735385/

Randomized Controlled Trial

BMC Musculoskelet Disord. 2023 Sep 21;24(1):748. doi:10.1186/s12891-023-06800-4.

Oral supplementation with fish cartilage hydrolysate in an adult population suffering from knee pain and function discomfort: results from an innovative approach combining an exploratory clinical study and an ex vivo clinical investigation

Henrotin Yves ^1 2, Julie Herman ³, Melanie Uebelhoer ³, Fabien Wauquier ⁴, Line Boutin-Wittrant ⁴, Anne-Françoise Donneau ⁵, Justine Monseur ⁵, Variance Mokam Fotso ³, Marie Duquenne ⁶, Mélanie Wagner ⁷, Elodie Bouvret ⁸, Bérénice Costes ³, Yohann Wittrant ^9 10

NOW 7 INTERNATIONAL PUBLICATIONS (and more to come) TO ATTEST THE ROBUSTNESS AND EFFICIENCY OF EX VIVO CLINICAL APPROACH – CLINIC’N’CELL

https://pubmed.ncbi.nlm.nih.gov/37111121/

Nutrients 2023 Apr 14;15(8):1903. doi: 10.3390/nu15081903.

Circulating Human Metabolites Resulting from TOTUM-070 Absorption (a Plant-Based, Polyphenol-Rich Ingredient) Improve Lipid Metabolism in Human Hepatocytes: Lessons from an Original Ex Vivo Clinical Trial

Fabien Wauquier ¹, Line Boutin-Wittrant ¹, Stéphanie Krisa ², Josep Valls ^2 3, Cedric Langhi ⁴, Yolanda F Otero ⁴, Pascal Sirvent ⁴, Sébastien Peltier ⁵, Maxime Bargetto ⁵, Murielle Cazaubiel ⁵, Véronique Sapone ⁵, Annie Bouchard-Mercier ⁶, Véronique Roux ⁷, Nicolas Macian ⁷, Gisèle Pickering ⁷, Yohann Wittrant ^8 9

clinicncell / clinic’n’cell

# EX VIVO CLINICAL TRIAL

https://www.ahajournals.org/doi/abs/10.1161/circ.146.suppl_1.11397?af=R

This clinical innovative approach provides robust human data regarding the health benefits of a product in faster, more affordable and more mechanistic ways (mode of action in humans) than any conventional clinical trial. Using human metabolites (circulating and bioavailable bioactives) this approach is more physiological than any in vitro test. The approach is also intended to be ethical since it allow to get rid of an animal experimentation. #clinicncell #clinic’n’cell

AND ONE MORE PUBLICATION… FOR CLINICNCELL = NOW 6 INTERNATIONAL PEER REVIEWED MANUSCRITS AND ONGOING

https://pubmed.ncbi.nlm.nih.gov/36501057/

Nutrients 2022 Nov 25;14(23):5027. doi: 10.3390/nu14235027

Benefits of Circulating Human Metabolites from Fish Cartilage Hydrolysate on Primary Human Dermal Fibroblasts, an Ex Vivo Clinical Investigation for Skin Health Applications.

Fabien Wauquier ¹, Line Boutin-Wittrant ¹, Elodie Bouvret ², Julie Le Faouder ², Véronique Roux ³, Nicolas Macian ³, Gisèle Pickering ³, Yohann Wittrant ^4 5

ClinicnCell