# EX VIVO CLINICAL TRIAL
Nutrients 2022 Nov 25;14(23):5027. doi: 10.3390/nu14235027
Benefits of Circulating Human Metabolites from Fish Cartilage Hydrolysate on Primary Human Dermal Fibroblasts, an Ex Vivo Clinical Investigation for Skin Health Applications.
Fabien Wauquier 1, Line Boutin-Wittrant 1, Elodie Bouvret 2, Julie Le Faouder 2, Véronique Roux 3, Nicolas Macian 3, Gisèle Pickering 3, Yohann Wittrant 4 5
This clinical innovation provides robust human data regarding the health benefits of a product in faster, more affordable and more mechanistic ways (mode of action in humans) than any conventional clinical trial. Using human metabolites (circulating and bioavailable bioactives) this approach is more physiological than any in vitro test. The approach is also intended to be ethical since it allow to get rid of an animal experimentation. #clinicncell #clinic’n’cell