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💪🧬🥇2024 / 10th INTERNATIONAL PEER-REVIEWED PUBLICATIONS – EX VIVO CLINICAL APPROACH – CLINIC’N’CELL

Biomedicines 2024, 12, 2132

https://doi.org/10.3390/biomedicines12092132

Human Serum, Following Absorption of Fish Cartilage Hydrolysate, Promotes Dermal Fibroblast Healing through Anti-Inflammatory and Immunomodulatory Proteins

Julie Le Faouder, Aurélie Guého, Régis Lavigne, Fabien Wauquier, Line Boutin-Wittrant,
Elodie Bouvret, Emmanuelle Com, Yohann Wittrant* and Charles Pineau* (*co last-authors)

💪🧬🥇2024 / 9th INTERNATIONAL PEER-REVIEWED PUBLICATIONS – EX VIVO CLINICAL APPROACH – CLINIC’N’CELL

https://pubmed.ncbi.nlm.nih.gov/38543230/

Pharmaceutics. 2024 Feb 28;16(3):336. doi: 10.3390/pharmaceutics16030336.

Reduced Production of Pro-Inflammatory and Pro-Catabolic Factors by Human Serum Metabolites Derived from a Patented Saffron Extract Intake

Line Pourtau 1Fabien Wauquier 2Line Boutin-Wittrant 2David Gaudout 1Benjamin Moras 1Adeline Vignault 1Carole Vaysse 3Tristan Richard 4 5Arnaud Courtois 4 5Stéphanie Krisa 4 5Véronique Roux 6Nicolas Macian 6Gisèle Pickering 6Yohann Wittrant 2 7 8

💪🧬🥇2024 / 8th INTERNATIONAL PEER-REVIEWED PUBLICATIONS TO ATTEST THE ROBUSTNESS AND EFFICIENCY OF EX VIVO CLINICAL APPROACH – CLINIC’N’CELL

https://pubmed.ncbi.nlm.nih.gov/37735385/

Randomized Controlled Trial

BMC Musculoskelet Disord. 2023 Sep 21;24(1):748. doi:10.1186/s12891-023-06800-4.

Oral supplementation with fish cartilage hydrolysate in an adult population suffering from knee pain and function discomfort: results from an innovative approach combining an exploratory clinical study and an ex vivo clinical investigation

Henrotin Yves 1 2Julie Herman 3Melanie Uebelhoer 3Fabien Wauquier 4Line Boutin-Wittrant 4Anne-Françoise Donneau 5Justine Monseur 5Variance Mokam Fotso 3Marie Duquenne 6Mélanie Wagner 7Elodie Bouvret 8Bérénice Costes 3Yohann Wittrant 9 10

💪🧬🥇NOW 7 INTERNATIONAL PUBLICATIONS (and more to come) TO ATTEST THE ROBUSTNESS AND EFFICIENCY OF EX VIVO CLINICAL APPROACH – CLINIC’N’CELL

https://pubmed.ncbi.nlm.nih.gov/37111121/

Nutrients 2023 Apr 14;15(8):1903. doi: 10.3390/nu15081903.

Circulating Human Metabolites Resulting from TOTUM-070 Absorption (a Plant-Based, Polyphenol-Rich Ingredient) Improve Lipid Metabolism in Human Hepatocytes: Lessons from an Original Ex Vivo Clinical Trial

Fabien Wauquier 1Line Boutin-Wittrant 1Stéphanie Krisa 2Josep Valls 2 3Cedric Langhi 4Yolanda F Otero 4Pascal Sirvent 4Sébastien Peltier 5Maxime Bargetto 5Murielle Cazaubiel 5Véronique Sapone 5Annie Bouchard-Mercier 6Véronique Roux 7Nicolas Macian 7Gisèle Pickering 7Yohann Wittrant 8 9

clinicncell / clinic’n’cell

# EX VIVO CLINICAL TRIAL

https://www.ahajournals.org/doi/abs/10.1161/circ.146.suppl_1.11397?af=R

This clinical innovative approach provides robust human data regarding the health benefits of a product in faster, more affordable and more mechanistic ways (mode of action in humans) than any conventional clinical trial. Using human metabolites (circulating and bioavailable bioactives) this approach is more physiological than any in vitro test. The approach is also intended to be ethical since it allow to get rid of an animal experimentation. #clinicncell #clinic’n’cell