Metabolic and Anti-Inflammatory Protective Properties of Human Enriched Serum Following Artichoke Leaf Extract Absorption: Results from an Innovative Ex Vivo Clinical Trial.

Wauquier F, Boutin-Wittrant L, Viret A, Guilhaudis L, Oulyadi H, Bourafai-Aziez A, Charpentier G, Rousselot G, Cassin E, Descamps S, Roux V, Macian N, Pickering G, Wittrant Y. /clinicncell.com

Nutrients. 2021 Jul 30;13(8):2653. doi: 10.3390/nu13082653. PMID: 34444810

Chondroprotective Properties of Human-Enriched Serum Following Polyphenol Extract Absorption: Results from an Exploratory Clinical Trial.

Wauquier F, Mevel E, Krisa S, Richard T, Valls J, Hornedo-Ortega R, Granel H, Boutin-Wittrant L, Urban N, Berger J, Descamps S, Guicheux J, Vinatier CS, Beck L, Meunier N, Blot A, Wittrant Y.

Nutrients. 2019 Dec 16;11(12):3071. doi: 10.3390/nu11123071. PMID: 31888255 / clinicncell.com

clinicncell.com

Non-targeted and targeted analysis of collagen hydrolysates during the course of digestion and absorption.

Kleinnijenhuis AJ, van Holthoon FL, Maathuis AJH, Vanhoecke B, Prawitt J, Wauquier F, Wittrant Y.

Anal Bioanal Chem. 2020 Feb;412(4):973-982.

doi: 10.1007/s00216-019-02323-x. PMID: 31872275 / clinicncell.com

Human Enriched Serum Following Hydrolysed Collagen Absorption Modulates Bone Cell Activity: from Bedside to Bench and Vice Versa.

Wauquier F, Daneault A, Granel H, Prawitt J, Fabien Soulé V, Berger J, Pereira B, Guicheux J, Rochefort GY, Meunier N, Blot A, Wittrant Y.

Nutrients. 2019 May 31;11(6):1249.

doi: 10.3390/nu11061249. PMID: 31159319 / clinicncell.com

Items 1-50 of 50 (Display the 50 citations in PubMed)

Metabolic and Anti-Inflammatory Protective Properties of Human Enriched Serum Following Artichoke Leaf Extract Absorption: Results from an Innovative Ex Vivo Clinical Trial. Wauquier F, Boutin-Wittrant L, Viret A, Guilhaudis L, Oulyadi H, Bourafai-Aziez A, Charpentier G, Rousselot G, Cassin E, Descamps S, Roux V, Macian N, Pickering G, Wittrant Y. Nutrients. 2021 Jul 30;13(8):2653. doi: 10.3390/nu13082653. PMID: 34444810 Free PMC article.
A new clinically-relevant rat model of letrozole-induced chronic nociceptive disorders. Collin A, Vein J, Wittrant Y, Pereira B, Amode R, Guillet C, Richard D, Eschalier A, Balayssac D. Toxicol Appl Pharmacol. 2021 Aug 15;425:115600. doi: 10.1016/j.taap.2021.115600. Epub 2021 Jun 1. PMID: 34081940
Chondroprotective Properties of Human-Enriched Serum Following Polyphenol Extract Absorption: Results from an Exploratory Clinical Trial. Wauquier F, Mevel E, Krisa S, Richard T, Valls J, Hornedo-Ortega R, Granel H, Boutin-Wittrant L, Urban N, Berger J, Descamps S, Guicheux J, Vinatier CS, Beck L, Meunier N, Blot A, Wittrant Y. Nutrients. 2019 Dec 16;11(12):3071. doi: 10.3390/nu11123071. PMID: 31888255 Free PMC article. Clinical Trial.
Non-targeted and targeted analysis of collagen hydrolysates during the course of digestion and absorption. Kleinnijenhuis AJ, van Holthoon FL, Maathuis AJH, Vanhoecke B, Prawitt J, Wauquier F, Wittrant Y. Anal Bioanal Chem. 2020 Feb;412(4):973-982. doi: 10.1007/s00216-019-02323-x. Epub 2019 Dec 24. PMID: 31872275 Free PMC article.
Lipid accumulation and mitochondrial abnormalities are associated with fiber atrophy in the skeletal muscle of rats with collagen-induced arthritis. Vial G, Coudy-Gandilhon C, Pinel A, Wauquier F, Chevenet C, Béchet D, Wittrant Y, Coxam V, Soubrier M, Tournadre A, Capel F. Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Feb;1865(2):158574. doi: 10.1016/j.bbalip.2019.158574. Epub 2019 Nov 17. PMID: 31747539
Mechanism of Calcium Incorporation Inside Sol-Gel Silicate Bioactive Glass and the Advantage of Using Ca(OH)2 over Other Calcium Sources. Bossard C, Granel H, Jallot É, Montouillout V, Fayon F, Soulié J, Drouet C, Wittrant Y, Lao J. ACS Biomater Sci Eng. 2019 Nov 11;5(11):5906-5915. doi: 10.1021/acsbiomaterials.9b01245. Epub 2019 Oct 18. PMID: 33405681
The effects of dietary fatty acids on bone, hematopoietic marrow and marrow adipose tissue in a murine model of senile osteoporosis. Bani Hassan E, Alderghaffar M, Wauquier F, Coxam V, Demontiero O, Vogrin S, Wittrant Y, Duque G. Aging (Albany NY). 2019 Sep 25;11(18):7938-7947. doi: 10.18632/aging.102299. Epub 2019 Sep 25. PMID: 31553309 Free PMC article.
Human Enriched Serum Following Hydrolysed Collagen Absorption Modulates Bone Cell Activity: from Bedside to Bench and Vice Versa. Wauquier F, Daneault A, Granel H, Prawitt J, Fabien Soulé V, Berger J, Pereira B, Guicheux J, Rochefort GY, Meunier N, Blot A, Wittrant Y. Nutrients. 2019 May 31;11(6):1249. doi: 10.3390/nu11061249. PMID: 31159319 Free PMC article.
Optimized Bioactive Glass: the Quest for the Bony Graft. Granel H, Bossard C, Nucke L, Wauquier F, Rochefort GY, Guicheux J, Jallot E, Lao J, Wittrant Y. Adv Healthc Mater. 2019 Jun;8(11):e1801542. doi: 10.1002/adhm.201801542. Epub 2019 Apr 3. PMID: 30941912 Review.
Berries, their micronutrients and bone health. Davicco MJ, Wittrant Y, Coxam V. Curr Opin Clin Nutr Metab Care. 2016 Nov;19(6):453-457. doi: 10.1097/MCO.0000000000000324. PMID: 27583710 Review.
Olive and grape seed extract prevents post-traumatic osteoarthritis damages and exhibits in vitro anti IL-1β activities before and after oral consumption. Mével E, Merceron C, Vinatier C, Krisa S, Richard T, Masson M, Lesoeur J, Hivernaud V, Gauthier O, Abadie J, Nourissat G, Houard X, Wittrant Y, Urban N, Beck L, Guicheux J. Sci Rep. 2016 Sep 19;6:33527. doi: 10.1038/srep33527. PMID: 27640363 Free PMC article.
GPR40 mediates potential positive effects of a saturated fatty acid enriched diet on bone. Philippe C, Wauquier F, Landrier JF, Bonnet L, Miot-Noirault E, Rochefort GY, Sadoine J, Asrih M, Jornayvaz FR, Bernalier A, Coxam V, Wittrant Y. Mol Nutr Food Res. 2017 Feb;61(2). doi: 10.1002/mnfr.201600219. Epub 2016 Nov 11. PMID: 27611773
Pinoresinol of olive oil decreases vitamin D intestinal absorption. Goncalves A, Margier M, Tagliaferri C, Lebecque P, Georgé S, Wittrant Y, Coxam V, Amiot MJ, Reboul E. Food Chem. 2016 Sep 1;206:234-8. doi: 10.1016/j.foodchem.2016.03.048. Epub 2016 Mar 16. PMID: 27041321
GPR40, a free fatty acid receptor, differentially impacts osteoblast behavior depending on differentiation stage and environment. Philippe C, Wauquier F, Lyan B, Coxam V, Wittrant Y. Mol Cell Biochem. 2016 Jan;412(1-2):197-208. doi: 10.1007/s11010-015-2626-5. Epub 2015 Dec 23. PMID: 26699911
The phenolic acids of Agen prunes (dried plums) or Agen prune juice concentrates do not account for the protective action on bone in a rat model of postmenopausal osteoporosis. Léotoing L, Wauquier F, Davicco MJ, Lebecque P, Gaudout D, Rey S, Vitrac X, Massenat L, Rashidi S, Wittrant Y, Coxam V. Nutr Res. 2016 Feb;36(2):161-73. doi: 10.1016/j.nutres.2015.10.002. Epub 2015 Oct 17. PMID: 26574736
Pomegranate Peel Extract Prevents Bone Loss in a Preclinical Model of Osteoporosis and Stimulates Osteoblastic Differentiation in Vitro. Spilmont M, Léotoing L, Davicco MJ, Lebecque P, Miot-Noirault E, Pilet P, Rios L, Wittrant Y, Coxam V. Nutrients. 2015 Nov 11;7(11):9265-84. doi: 10.3390/nu7115465. PMID: 26569295 Free PMC article.
Biological effect of hydrolyzed collagen on bone metabolism. Daneault A, Prawitt J, Fabien Soulé V, Coxam V, Wittrant Y. Crit Rev Food Sci Nutr. 2017 Jun 13;57(9):1922-1937. doi: 10.1080/10408398.2015.1038377. PMID: 25976422 Review.
Pros and cons of fatty acids in bone biology. Wauquier F, Léotoing L, Philippe C, Spilmont M, Coxam V, Wittrant Y. Prog Lipid Res. 2015 Apr;58:121-45. doi: 10.1016/j.plipres.2015.03.001. Epub 2015 Mar 30. PMID: 25835096 Review.
Muscle and bone, two interconnected tissues. Tagliaferri C, Wittrant Y, Davicco MJ, Walrand S, Coxam V. Ageing Res Rev. 2015 May;21:55-70. doi: 10.1016/j.arr.2015.03.002. Epub 2015 Mar 21. PMID: 25804855 Review.
Deficiency of G-protein coupled receptor 40, a lipid-activated receptor, heightens in vitro- and in vivo-induced murine osteoarthritis. Monfoulet LE, Philippe C, Mercier S, Coxam V, Wittrant Y. Exp Biol Med (Maywood). 2015 Jul;240(7):854-66. doi: 10.1177/1535370214565078. Epub 2015 Jan 13. PMID: 25585625 Free PMC article.
Olive oil and vitamin D synergistically prevent bone loss in mice. Tagliaferri C, Davicco MJ, Lebecque P, Georgé S, Amiot MJ, Mercier S, Dhaussy A, Huertas A, Walrand S, Wittrant Y, Coxam V. PLoS One. 2014 Dec 31;9(12):e115817. doi: 10.1371/journal.pone.0115817. eCollection 2014. PMID: 25551374 Free PMC article.
Increased body fat mass and tissue lipotoxicity associated with ovariectomy or high-fat diet differentially affects bone and skeletal muscle metabolism in rats. Tagliaferri C, Salles J, Landrier JF, Giraudet C, Patrac V, Lebecque P, Davicco MJ, Chanet A, Pouyet C, Dhaussy A, Huertas A, Boirie Y, Wittrant Y, Coxam V, Walrand S. Eur J Nutr. 2015 Oct;54(7):1139-49. doi: 10.1007/s00394-014-0790-0. Epub 2014 Nov 5. PMID: 25370302
Nutraceuticals in joint health: animal models as instrumental tools. Mével E, Monfoulet LE, Merceron C, Coxam V, Wittrant Y, Beck L, Guicheux J. Drug Discov Today. 2014 Oct;19(10):1649-58. doi: 10.1016/j.drudis.2014.06.012. Epub 2014 Jun 20. PMID: 24955836 Review.
The flavonoid fisetin promotes osteoblasts differentiation through Runx2 transcriptional activity. Léotoing L, Davicco MJ, Lebecque P, Wittrant Y, Coxam V. Mol Nutr Food Res. 2014 Jun;58(6):1239-48. doi: 10.1002/mnfr.201300836. Epub 2014 Feb 18. PMID: 24535991
Pomegranate and its derivatives can improve bone health through decreased inflammation and oxidative stress in an animal model of postmenopausal osteoporosis. Spilmont M, Léotoing L, Davicco MJ, Lebecque P, Mercier S, Miot-Noirault E, Pilet P, Rios L, Wittrant Y, Coxam V. Eur J Nutr. 2014 Aug;53(5):1155-64. doi: 10.1007/s00394-013-0615-6. PMID: 24232379
GW9508, a free fatty acid receptor agonist, specifically induces cell death in bone resorbing precursor cells through increased oxidative stress from mitochondrial origin. Philippe C, Wauquier F, Léotoing L, Coxam V, Wittrant Y. Exp Cell Res. 2013 Nov 15;319(19):3035-41. doi: 10.1016/j.yexcr.2013.08.013. Epub 2013 Aug 22. PMID: 23973666
Pomegranate seed oil prevents bone loss in a mice model of osteoporosis, through osteoblastic stimulation, osteoclastic inhibition and decreased inflammatory status. Spilmont M, Léotoing L, Davicco MJ, Lebecque P, Mercier S, Miot-Noirault E, Pilet P, Rios L, Wittrant Y, Coxam V. J Nutr Biochem. 2013 Nov;24(11):1840-8. doi: 10.1016/j.jnutbio.2013.04.005. Epub 2013 Aug 15. PMID: 23953990
The polyphenol fisetin protects bone by repressing NF-κB and MKP-1-dependent signaling pathways in osteoclasts. Léotoing L, Wauquier F, Guicheux J, Miot-Noirault E, Wittrant Y, Coxam V. PLoS One. 2013 Jul 4;8(7):e68388. doi: 10.1371/journal.pone.0068388. Print 2013. PMID: 23861901 Free PMC article.
The free fatty acid receptor G protein-coupled receptor 40 (GPR40) protects from bone loss through inhibition of osteoclast differentiation. Wauquier F, Philippe C, Léotoing L, Mercier S, Davicco MJ, Lebecque P, Guicheux J, Pilet P, Miot-Noirault E, Poitout V, Alquier T, Coxam V, Wittrant Y. J Biol Chem. 2013 Mar 1;288(9):6542-51. doi: 10.1074/jbc.M112.429084. Epub 2013 Jan 18. PMID: 23335512 Free PMC article.
Borage and fish oils lifelong supplementation decreases inflammation and improves bone health in a murine model of senile osteoporosis. Wauquier F, Barquissau V, Léotoing L, Davicco MJ, Lebecque P, Mercier S, Philippe C, Miot-Noirault E, Chardigny JM, Morio B, Wittrant Y, Coxam V. Bone. 2012 Feb;50(2):553-61. doi: 10.1016/j.bone.2011.05.030. Epub 2011 Jun 6. PMID: 21664309
Inorganic phosphate stimulates apoptosis in murine MO6-G3 odontoblast-like cells. Bourgine A, Beck L, Khoshniat S, Wauquier F, Oliver L, Hue E, Alliot-Licht B, Weiss P, Guicheux J, Wittrant Y. Arch Oral Biol. 2011 Oct;56(10):977-83. doi: 10.1016/j.archoralbio.2011.03.001. Epub 2011 Mar 23. PMID: 21435634
Prebiotic effects: metabolic and health benefits. Roberfroid M, Gibson GR, Hoyles L, McCartney AL, Rastall R, Rowland I, Wolvers D, Watzl B, Szajewska H, Stahl B, Guarner F, Respondek F, Whelan K, Coxam V, Davicco MJ, Léotoing L, Wittrant Y, Delzenne NM, Cani PD, Neyrinck AM, Meheust A. Br J Nutr. 2010 Aug;104 Suppl 2:S1-63. doi: 10.1017/S0007114510003363. PMID: 20920376 Review.
Gallium modulates osteoclastic bone resorption in vitro without affecting osteoblasts. Verron E, Masson M, Khoshniat S, Duplomb L, Wittrant Y, Baud’huin M, Badran Z, Bujoli B, Janvier P, Scimeca JC, Bouler JM, Guicheux J. Br J Pharmacol. 2010 Apr;159(8):1681-92. doi: 10.1111/j.1476-5381.2010.00665.x. PMID: 20397300 Free PMC article.
Colony-stimulating factor-1 (CSF-1) directly inhibits receptor activator of nuclear factor-{kappa}B ligand (RANKL) expression by osteoblasts. Wittrant Y, Gorin Y, Mohan S, Wagner B, Abboud-Werner SL. Endocrinology. 2009 Nov;150(11):4977-88. doi: 10.1210/en.2009-0248. Epub 2009 Oct 9. PMID: 19819976 Free PMC article.
Oxidative stress in bone remodelling and disease. Wauquier F, Leotoing L, Coxam V, Guicheux J, Wittrant Y. Trends Mol Med. 2009 Oct;15(10):468-77. doi: 10.1016/j.molmed.2009.08.004. Epub 2009 Oct 5. PMID: 19811952 Review.
Phosphate-dependent regulation of MGP in osteoblasts: role of ERK1/2 and Fra-1. Julien M, Khoshniat S, Lacreusette A, Gatius M, Bozec A, Wagner EF, Wittrant Y, Masson M, Weiss P, Beck L, Magne D, Guicheux J. J Bone Miner Res. 2009 Nov;24(11):1856-68. doi: 10.1359/jbmr.090508. PMID: 19419315
Inorganic phosphate regulates Glvr-1 and -2 expression: role of calcium and ERK1/2. Wittrant Y, Bourgine A, Khoshniat S, Alliot-Licht B, Masson M, Gatius M, Rouillon T, Weiss P, Beck L, Guicheux J. Biochem Biophys Res Commun. 2009 Apr 3;381(2):259-63. doi: 10.1016/j.bbrc.2009.02.034. Epub 2009 Feb 14. PMID: 19232318
Killer dendritic cells link innate and adaptive immunity against established osteosarcoma in rats. Chauvin C, Philippeau JM, Hémont C, Hubert FX, Wittrant Y, Lamoureux F, Trinité B, Heymann D, Rédini F, Josien R. Cancer Res. 2008 Nov 15;68(22):9433-40. doi: 10.1158/0008-5472.CAN-08-0104. PMID: 19010918
Nox4 NAD(P)H oxidase mediates Src-dependent tyrosine phosphorylation of PDK-1 in response to angiotensin II: role in mesangial cell hypertrophy and fibronectin expression. Block K, Eid A, Griendling KK, Lee DY, Wittrant Y, Gorin Y. J Biol Chem. 2008 Aug 29;283(35):24061-76. doi: 10.1074/jbc.M803964200. Epub 2008 Jun 16. PMID: 18559349 Free PMC article.
High d(+)glucose concentration inhibits RANKL-induced osteoclastogenesis. Wittrant Y, Gorin Y, Woodruff K, Horn D, Abboud HE, Mohan S, Abboud-Werner SL. Bone. 2008 Jun;42(6):1122-30. doi: 10.1016/j.bone.2008.02.006. Epub 2008 Feb 29. PMID: 18378205 Free PMC article.
PDGF up-regulates CSF-1 gene transcription in ameloblast-like cells. Wittrant Y, Bhandari BS, Abboud H, Benson N, Woodruff K, MacDougall M, Abboud-Werner S. J Dent Res. 2008 Jan;87(1):33-8. doi: 10.1177/154405910808700105. PMID: 18096890
Therapeutic relevance of osteoprotegerin gene therapy in osteosarcoma: blockade of the vicious cycle between tumor cell proliferation and bone resorption. Lamoureux F, Richard P, Wittrant Y, Battaglia S, Pilet P, Trichet V, Blanchard F, Gouin F, Pitard B, Heymann D, Redini F. Cancer Res. 2007 Aug 1;67(15):7308-18. doi: 10.1158/0008-5472.CAN-06-4130. PMID: 17671200
Targeted expression of csCSF-1 in op/op mice ameliorates tooth defects. Werner SA, Gluhak-Heinrich J, Woodruff K, Wittrant Y, Cardenas L, Roudier M, MacDougall M. Arch Oral Biol. 2007 May;52(5):432-43. doi: 10.1016/j.archoralbio.2006.10.018. Epub 2006 Nov 28. PMID: 17126805 Free PMC article.
RANKL directly induces bone morphogenetic protein-2 expression in RANK-expressing POS-1 osteosarcoma cells. Wittrant Y, Lamoureux F, Mori K, Riet A, Kamijo A, Heymann D, Redini F. Int J Oncol. 2006 Jan;28(1):261-9. PMID: 16328004
The molecular triad OPG/RANK/RANKL: involvement in the orchestration of pathophysiological bone remodeling. Theoleyre S, Wittrant Y, Tat SK, Fortun Y, Redini F, Heymann D. Cytokine Growth Factor Rev. 2004 Dec;15(6):457-75. doi: 10.1016/j.cytogfr.2004.06.004. PMID: 15561602 Review.
RANKL/RANK/OPG: new therapeutic targets in bone tumours and associated osteolysis. Wittrant Y, Théoleyre S, Chipoy C, Padrines M, Blanchard F, Heymann D, Rédini F. Biochim Biophys Acta. 2004 Sep 20;1704(2):49-57. doi: 10.1016/j.bbcan.2004.05.002. PMID: 15363860 Review.
Cellular activity and signaling induced by osteoprotegerin in osteoclasts: involvement of receptor activator of nuclear factor kappaB ligand and MAPK. Theoleyre S, Wittrant Y, Couillaud S, Vusio P, Berreur M, Dunstan C, Blanchard F, Rédini F, Heymann D. Biochim Biophys Acta. 2004 Feb 2;1644(1):1-7. doi: 10.1016/j.bbamcr.2003.10.005. PMID: 14741739
Relevance of an in vitro osteoclastogenesis system to study receptor activator of NF-kB ligand and osteoprotegerin biological activities. Wittrant Y, Theoleyre S, Couillaud S, Dunstan C, Heymann D, Rédini F. Exp Cell Res. 2004 Feb 15;293(2):292-301. doi: 10.1016/j.yexcr.2003.10.016. PMID: 14729467
Regulation of osteoclast protease expression by RANKL. Wittrant Y, Theoleyre S, Couillaud S, Dunstan C, Heymann D, Rédini F. Biochem Biophys Res Commun. 2003 Oct 24;310(3):774-8. doi: 10.1016/j.bbrc.2003.09.084. PMID: 14550270
Osteoprotegerin differentially regulates protease expression in osteoclast cultures. Wittrant Y, Couillaud S, Theoleyre S, Dunstan C, Heymann D, Rédini F. Biochem Biophys Res Commun. 2002 Apr 26;293(1):38-44. doi: 10.1016/S0006-291X(02)00179-1. PMID: 12054560